Subfecundity İn Overweight And Obese Couples
C.H.Ramlau-Hansen1,2,5, A.M.Thulstrup2, E.A.Nohr3, J.P.Bonde2, T.I.A.Sørensen4 and J.Olsen1
1Department of Epidemiology, UCLA School of Public Health, Los Angeles, CA, USA, 2Department of Occupational Medicine, Aarhus University Hospital, Aarhus C, Denmark, 3Department of Epidemiology, Institute of Public Health, University of Aarhus, Aarhus C, Denmark and 4Institute of Preventive Medicine, Centre for Health and Society, Copenhagen University Hospital, Copenhagen K, Denmark
5To whom correspondence should be addressed at: Department of Epidemiology, UCLA School of Public Health, 71-254 CHS, 650 Charles E. Young Dr. S., Los Angeles, CA 90095-1772, USA. E-mail: craha@as.aaa.dk
BACKGROUND: Recent studies indicate that not only women’s but also men’s obesity has adverse effects on fecundity and since fecundity is a couple concept, we examined fecundity in relation to overweight and obesity of the couple. We also examined the association between weight changes and fecundity over time.
METHODS: Between 1996 and 2002, 64 167 pregnant women enrolled in the Danish National Birth Cohort were interviewed during and 18 months after pregnancy. Information on body mass index (BMI) and waiting time to pregnancy (TTP) was available for 47 835 couples.
RESULTS: Among men and women with a BMI of 18.5 kg/m2 or more, we found a dose-response relationship between increasing BMI group and subfecundity (a TTP of more than 12 months): Odds ratio (OR) 5 1.32 (95% CI: 1.26–1.37) for women and OR 5 1.19 (95% CI: 1.14–1.24) for men. Among
2374 women with an initial BMI of 18.5 kg/m2 or more, who participated more than once in the Danish National Birth Cohort, each kilogram increment in weight between the two pregnancies was associated with a 2.84 (95% CI: 1.33–4.35) days longer TTP.
CONCLUSIONS: Couples have a high risk of being subfecund if they are both obese.
